Slide DMS120 [Lymph gland, monkey, H&E] A lymph node ("gland") is an encapsulated lymphoid organ. This slide has longitudinal sections of one or more nodes and is good for general histological features. Identify afferent and efferent lymph vessels (some with valves), capsule, subcapsular sinus (and the abundant macrophages therein), cortex with lymphoid nodules and medulla with medullary cords and sinuses. Depending on the plane of section, you may or may not be able to find the hilum. Note that the cortex is divided into a superficial (containing nodules) and a deep portion (paracortex). Which portions are "B cell-dependent," and which are "T cell-dependent" ? Note that lymph nodes are well supplied with both blood and lymph vessels. Look in the paracortex for high endothelial venules (HEV), the site where most circulating lymphocytes enter the node. If a small group of cells breaks off from a malignant tumor and enters a lymphatic vessel it will be filtered out by a lymph node. In what part of the node will it most likely lodge?